Stem Cells Treat Urinary Incontinence

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Stem Cells Treat Urinary Incontinence

Women with stress urinary incontinence (SUI) were treated with muscle derived stem cell injections to strengthen sphincter muscles. This study was based on the finding that injecting stem cells into the urethral muscles increases leak point pressure which restores deficient muscle. Skeletal muscle tissue biopsies were isolated and expanded in culture from 7 patients. Out-patient transurethral injections were administered into the peri-urethral region with an 8mm or 10mm needle. 5 women reported improvement in bladder control control and quality of life without serious adverse effects. However, the 8mm needle was incapable of reaching the sphincter. The optimal dose of muscle stem cells required to effectively treat SUI. 13 million women have SUI in the United States, commonly caused by childbirth, menopause or pelvic surgery. This research from the University of Pittsburgh School of Medicine, United States and Sunnybrook Health Sciences, Toronto, Canada was presented at the annual meeting of the American Urological Association. Professor Chancellor told the IJS: “We’re demonstrating for the first time that we may be able to offer people with SUI a long-term and minimally invasive treatment.” Abstract 1185 in the AUA proceedings.